DIMETHYL DL-GLUTAMATE HYDROCHLORIDE
- Product Name
- DIMETHYL DL-GLUTAMATE HYDROCHLORIDE
- CAS No.
- 13515-99-6
- Chemical Name
- DIMETHYL DL-GLUTAMATE HYDROCHLORIDE
- Synonyms
- utamate HydrochL;H-DL-Glu(Ome)-Ome;DL-Glu(OMe)-OMe.HCl;H-DL-GLU(OME)-OME HCL;DIMETHYL DL-GLUTAMATE HYDROCHLORIDE;DimethylDL-GlutamateHydrochloride>imethyl2-aminopentanedioate,hydrochloride;dimethyl 2-aminopentanedioate hydrochloride;DL-GLUTAMIC ACID DIMETHYL ESTER HYDROCHLORIDE;DIMETHYL DL-GLUTAMATE HYDROCHLORIDE USP/EP/BP
- CBNumber
- CB1152575
- Molecular Formula
- C7H14ClNO4
- Formula Weight
- 211.64
- MOL File
- 13515-99-6.mol
DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Property
- Melting point:
- 154 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- CAS DataBase Reference
- 13515-99-6
Safety
- HS Code
- 2922.42.5000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D3305
- Product name
- Dimethyl DL-Glutamate Hydrochloride
- Purity
- >98.0%(N)(T)
- Packaging
- 5g
- Price
- $42
- Updated
- 2024/03/01
- Product number
- D3305
- Product name
- Dimethyl DL-Glutamate Hydrochloride
- Purity
- >98.0%(N)(T)
- Packaging
- 25g
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 18602
- Product name
- Dimethyl DL-Glutamate (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 18602
- Product name
- Dimethyl DL-Glutamate (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10g
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 18602
- Product name
- Dimethyl DL-Glutamate (hydrochloride)
- Purity
- ≥95%
- Packaging
- 25g
- Price
- $302
- Updated
- 2024/03/01
DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Chemical Properties,Usage,Production
Description
While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles. Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide and glucagon-like peptide 1. Dimethyl DL-glutamate is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells. However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.
Uses
While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles. Dimethyl DL-glutamate Hydrochloride is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide and glucagon-like peptide 1. Dimethyl DL-glutamate Hydrochloride is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells. However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.
in vitro
dimethyl dl-glutamate at 3.0-10.0 mm could enhance insulin release evoked by 6.0-8.3 mm d-glucose, 1.0-10.0 mm l-leucine, or 5.0-10.0 mm 2-amino-bicyclo(2,2,1)heptane-2-carboxylic acid, resulting in a shift to the left of the sigmoidal relationship between insulin output and d-glucose concentration. moreover, dimethyl dl-glutamate unmasked the insulinotropic potential of glibenclamide in the absence of d-glucose. in islets exposed to l-leucine, the insulinotropic action of dimethyl dl-glutamate coincided with an early fall and later increase in 86rb outflow. in addition, the overall gain in o2 uptake represented the balance between dimethyl dl-glutamate oxidation and its sparing action on the catabolism of endogenous fatty acids and exogenous d-glucose [1].
in vivo
dimethyl dl-glutamate was intravenously administered as a primed constant infusion to adult rats that had been injected with streptozotocin during the neonatal period. results showed that dimethyl dl-glutamate augmented plasma insulin concentration and potentiated and/or prolonged the insulinotropic action of glp-1 injected intravenously at min 5 of the test [2].
References
[1] sener, a. ,conget, i.,rasschaert, j., et al. insulinotropic action of glutamic acid dimethyl ester. american journal of physiology 267(4 pt 1), e573-e584 (1994).
[2] cancelas, j. ,villaneuva-peacarrillo, m.l.,valverde, i., et al. potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of l-glutamic acid in a type 2 diabetes animal model. endocrine 16(2), 113-116 (2001).
DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Suppliers
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View Lastest Price from DIMETHYL DL-GLUTAMATE HYDROCHLORIDE manufacturers
- Product
- DL-Glu(Ome)-Ome.Hcl 13515-99-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-23
- Product
- DIMETHYL DL-GLUTAMATE HYDROCHLORIDE 13515-99-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-22